Lip and Oral Cavity Squamous Cell Carcinoma

Adam Howard; Nishant Agrawal; Zhen Gooi

doi:10.1016/j.hoc.2021.05.003

Lip and Oral Cavity Squamous Cell Carcinoma

Hematol Oncol Clin North Am. 2021 Oct;35(5):895-911. doi: 10.1016/j.hoc.2021.05.003. Epub 2021 Jul 14.

Authors

Adam Howard¹, Nishant Agrawal¹, Zhen Gooi²

Affiliations

¹ University of Chicago, 5841 South Maryland Avenue, MC 1035, Chicago, IL 60637, USA.
² University of Chicago, 5841 South Maryland Avenue, MC 1035, Chicago, IL 60637, USA. Electronic address: zgooi@surgery.bsd.uchicago.edu.

PMID: 34274176
DOI: 10.1016/j.hoc.2021.05.003

Abstract

Lip and oral cavity squamous cell carcinoma (SCC) develop from progressive dysplasia of these mucosal structures. The cancers are often preceded by premalignant lesions, and any nonhealing ulcers of the lip or oral cavity should be biopsied. Some risk factors for these 2 subsites overlap and include tobacco use, alcohol use, and an immunocompromised state. Lip and oral cavity SCC are clinically staged based on physical examination and imaging. The 5-year overall survival for early-stage lip and oral cavity SCC is around 70% to 90% but decreases to about 50% for late-stage disease.

Keywords: Head and neck cancer; Lip cancer; Oral cavity cancer; Squamous cell carcinoma.

Publication types

Review

MeSH terms

Carcinoma, Squamous Cell*
Head and Neck Neoplasms*
Humans
Lip
Mouth Neoplasms* / diagnosis
Mouth Neoplasms* / therapy
Squamous Cell Carcinoma of Head and Neck