Mesenchymal stem cells: ideal seeds for treating diseases

Hum Cell. 2021 Nov;34(6):1585-1600. doi: 10.1007/s13577-021-00578-0. Epub 2021 Jul 16.

Abstract

Mesenchymal stem cells (MSCs), a kind of multipotent stem cells with self-renewal ability and multi-differentiation ability, have become the "practical stem cells" for the treatment of diseases. MSCs have immunomodulatory properties and can be used to treat autoimmune diseases, such as systemic lupus erythematosus (SLE) and Crohn's disease. MSCs also can be used in cancer and aging. At present, many clinical experiments are using MSCs. MSCs can reduce the occurrence of inflammation and apoptosis of tissue cells, and promote the proliferation of endogenous tissue and organ cells, so as to achieve the effect of repairing tissue and organs. MSCs presumably also play an important role in Corona Virus Disease 2019 (COVID-19) infection.

Keywords: Aging; Autoimmune diseases; COVID-19; Cancer; Inflammation; Mesenchymal stem cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Autoimmune Diseases / therapy
  • COVID-19 / therapy*
  • Cell Proliferation
  • Cell- and Tissue-Based Therapy / methods*
  • Cell- and Tissue-Based Therapy / trends
  • Crohn Disease / therapy
  • Humans
  • Immunomodulation
  • Inflammation
  • Lupus Erythematosus, Systemic / therapy
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stem Cells* / immunology
  • Mice
  • Neoplasms / therapy