G-protein-coupled receptors as therapeutic targets for glioblastoma

Kate F Byrne; Ajay Pal; James F Curtin; John C Stephens; Gemma K Kinsella

doi:10.1016/j.drudis.2021.07.008

G-protein-coupled receptors as therapeutic targets for glioblastoma

Drug Discov Today. 2021 Dec;26(12):2858-2870. doi: 10.1016/j.drudis.2021.07.008. Epub 2021 Jul 14.

Authors

Kate F Byrne¹, Ajay Pal², James F Curtin², John C Stephens³, Gemma K Kinsella⁴

Affiliations

¹ School of Food Science and Environmental Health, College of Sciences and Health, Technological University Dublin, Dublin D07 ADY7, Ireland; Environmental Sustainability and Health Institute (ESHI), Grangegorman, Technological University Dublin, Dublin D07 H6K8, Ireland.
² School of Food Science and Environmental Health, College of Sciences and Health, Technological University Dublin, Dublin D07 ADY7, Ireland.
³ Department of Chemistry, Maynooth University, Maynooth, Co. Kildare, Ireland; Kathleen Lonsdale Institute for Human Health Research, Maynooth University, Maynooth, Co. Kildare, Ireland.
⁴ School of Food Science and Environmental Health, College of Sciences and Health, Technological University Dublin, Dublin D07 ADY7, Ireland. Electronic address: gemma.kinsella@tudublin.ie.

PMID: 34271165
DOI: 10.1016/j.drudis.2021.07.008

Abstract

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumour in adults. Treatments include surgical resection, radiotherapy, and chemotherapy. Despite this, the prognosis remains poor, with an impacted quality of life during treatment coupled with brain tumour recurrence; thus, new treatments are desperately needed. In this review, we focus on recent advances in G-protein-coupled receptor (GPCR) targets. To date, the most promising targets are the chemokine, cannabinoid, and dopamine receptors, but future work should further examine the melanocortin receptor-4 (MC4R), adhesion, lysophosphatidic acid (LPA) and smoothened (Smo) receptors to initiate new drug-screening strategies and targeted delivery of safe and effective GBM therapies.

Keywords: G-protein-coupled receptors (GPCRs); Glioblastoma multiforme (GBM).

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adult
Animals
Antineoplastic Agents / pharmacology
Brain Neoplasms / drug therapy*
Brain Neoplasms / pathology
Drug Development
Glioblastoma / drug therapy*
Glioblastoma / pathology
Humans
Molecular Targeted Therapy
Neoplasm Recurrence, Local
Prognosis
Quality of Life
Receptors, G-Protein-Coupled / metabolism*

Substances

Antineoplastic Agents
Receptors, G-Protein-Coupled