AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs

Javier Díaz-Alonso; Roger A Nicoll

doi:10.1016/j.neuropharm.2021.108710

AMPA receptor trafficking and LTP: Carboxy-termini, amino-termini and TARPs

Neuropharmacology. 2021 Oct 1:197:108710. doi: 10.1016/j.neuropharm.2021.108710. Epub 2021 Jul 13.

Authors

Javier Díaz-Alonso¹, Roger A Nicoll²

Affiliations

¹ Department of Anatomy and Neurobiology, USA; Center for the Neurobiology of Learning and Memory, University of California at Irvine, USA. Electronic address: jdiazalo@uci.edu.
² Departments of Cellular and Molecular Pharmacology, USA; Physiology, University of California at San Francisco, USA. Electronic address: roger.nicoll@ucsf.edu.

Abstract

AMPA receptors (AMPARs) are fundamental elements in excitatory synaptic transmission and synaptic plasticity in the CNS. Long term potentiation (LTP), a form of synaptic plasticity which contributes to learning and memory formation, relies on the accumulation of AMPARs at the postsynapse. This phenomenon requires the coordinated recruitment of different elements in the AMPAR complex. Based on recent research reviewed herein, we propose an updated AMPAR trafficking and LTP model which incorporates both extracellular as well as intracellular mechanisms. This article is part of the special Issue on 'Glutamate Receptors - AMPA receptors'.

Keywords: AMPA receptor; AMPAR amino-terminal domain; LTP; Long-term potentiation; Synaptic plasticity; TARP.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Long-Term Potentiation / genetics
Long-Term Potentiation / physiology*
Receptors, AMPA / genetics
Receptors, AMPA / metabolism
Receptors, AMPA / physiology*

Substances

Receptors, AMPA

Abstract

Publication types

MeSH terms

Substances

Grants and funding