T Cell Protein Tyrosine Phosphatase in Glucose Metabolism

Ya-Nan Wang; Shiyue Liu; Tingting Jia; Yao Feng; Xin Xu; Dongjiao Zhang

doi:10.3389/fcell.2021.682947

T Cell Protein Tyrosine Phosphatase in Glucose Metabolism

Front Cell Dev Biol. 2021 Jun 29:9:682947. doi: 10.3389/fcell.2021.682947. eCollection 2021.

Authors

Ya-Nan Wang^{1

2

3}, Shiyue Liu^{2

3

4}, Tingting Jia^{1

2

3}, Yao Feng^{1

2

3}, Xin Xu^{1

2

3}, Dongjiao Zhang^{1

2

3}

Affiliations

¹ Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China.
² Shandong Key Laboratory of Oral Tissue Regeneration, Jinan, China.
³ Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China.
⁴ Department of Periodontology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, China.

Abstract

T cell protein tyrosine phosphatase (TCPTP), a vital regulator in glucose metabolism, inflammatory responses, and tumor processes, is increasingly considered a promising target for disease treatments and illness control. This review discusses the structure, substrates and main biological functions of TCPTP, as well as its regulatory effect in glucose metabolism, as an attempt to be referenced for formulating treatment strategies of metabolic disorders. Given the complicated regulation functions in different tissues and organs of TCPTP, the development of drugs inhibiting TCPTP with a higher specificity and a better biocompatibility is recognized as a promising therapeutic strategy for diabetes or obesity. Besides, treatments targeting TCPTP in a specific tissue or organ are suggested to be considerably promising.

Keywords: T cell protein tyrosine phosphatase; glucose metabolism; insulin signaling pathway; leptin signaling pathway; protein tyrosine phosphatase non-receptor 2.

Publication types

Review