Development of custom lead shield and strainer for targeted irradiation for mice in the gamma cell chamber

Nurhaslina Hasan; Nur Fatihah Ronny Sham; Muhammad Khalis Abdul Karim; Syed Baharom Syed Ahmad Fuad; Narimah Abdul Hamid Hasani; Effat Omar; Mohammad Johari Ibahim

doi:10.1038/s41598-021-93964-5

Development of custom lead shield and strainer for targeted irradiation for mice in the gamma cell chamber

Sci Rep. 2021 Jul 15;11(1):14559. doi: 10.1038/s41598-021-93964-5.

Authors

Nurhaslina Hasan^{1

2}, Nur Fatihah Ronny Sham¹, Muhammad Khalis Abdul Karim³, Syed Baharom Syed Ahmad Fuad¹, Narimah Abdul Hamid Hasani¹, Effat Omar¹, Mohammad Johari Ibahim⁴

Affiliations

¹ Faculty of Medicine, Universiti Teknologi MARA, 47200, Sungai Buloh, Selangor, Malaysia.
² Faculty of Dentistry, Universiti Teknologi MARA, 47200, Sungai Buloh, Selangor, Malaysia.
³ Faculty of Science, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
⁴ Faculty of Medicine, Universiti Teknologi MARA, 47200, Sungai Buloh, Selangor, Malaysia. mji@uitm.edu.my.

Abstract

We presented a development of a custom lead shield and mouse strainer for targeted irradiation from the gamma-cell chamber. This study was divided into two parts i.e., to (i) fabricate the shield and strainer from a lead (Pb) and (ii) optimize the irradiation to the mice-bearing tumour model with 2 and 8 Gy absorbed doses. The lead shielding was fabricated into a cuboid shape with a canal on the top and a hole on the vertical side for the beam path. Respective deliveries doses of 28 and 75 Gy from gamma-cell were used to achieve 2 and 8 Gy absorbed doses at the tumour sites.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Equipment Design
Female
Film Dosimetry / methods
Gamma Rays
Lead
Mice
Mice, Inbred BALB C
Neoplasms, Experimental / radiotherapy*
Radiation Protection / instrumentation*
Radiation Protection / methods*
Radiotherapy Dosage

Substances

Lead