Adequate supply of long-chain polyunsaturated fatty acids (LCPUFAs) is of great importance for neonates, especially preterm infants. In particular, n-3 LCPUFAs and n-6 LCPUFAs play a key role in brain development, immune regulation, and disease prevention. Lack of LCPUFAs may lead to neurodevelopmental impairment, affect the development of neonatal immune system, and result in neonatal diseases. This article reviews related research advances in the physiological function of LCPUFAs and its effect on neonates, so as to provide reference for clinical application.
充足的长链多不饱和脂肪酸(long-chain polyunsaturated fatty acids，LCPUFAs)供给对新生儿，特别是早产儿可能至关重要，尤其是n-3系列和n-6系列的LCPUFAs，在大脑发育、免疫调节和疾病预防中都有重要的作用。LCPUFAs的缺乏可能会导致神经发育受损，影响新生儿免疫系统发育并导致新生儿疾病的发生。该文综述了LCPUFAs的生理功能及其对新生儿的影响的相关研究进展，以期为临床应用提供参考。