Fabrication of Zein-Lecithin-EGCG complex nanoparticles: Characterization, controlled release in simulated gastrointestinal digestion

Hujun Xie; Chengzhi Liu; Jian Gao; Jieyu Shi; Fangfang Ni; Xin Luo; Ying He; Gerui Ren; Zisheng Luo

doi:10.1016/j.foodchem.2021.130542

Fabrication of Zein-Lecithin-EGCG complex nanoparticles: Characterization, controlled release in simulated gastrointestinal digestion

Food Chem. 2021 Dec 15:365:130542. doi: 10.1016/j.foodchem.2021.130542. Epub 2021 Jul 6.

Authors

Hujun Xie¹, Chengzhi Liu², Jian Gao², Jieyu Shi², Fangfang Ni², Xin Luo², Ying He², Gerui Ren², Zisheng Luo³

Affiliations

¹ School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, People's Republic of China. Electronic address: hujunxie@gmail.com.
² School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, People's Republic of China.
³ College of Biosystems Engineering and Food Science, Key Laboratory of Agro-Products Postharvest Handling of Ministry of Agriculture and Rural Affairs, Zhejiang Key Laboratory for Agro-Food Processing, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang University, Hangzhou 310058, People's Republic of China; Ningbo Research Institute, Zhejiang University, Ningbo 315100, People's Republic of China; Fuli Institute of Food Science, Hangzhou 310018, People's Republic of China. Electronic address: luozisheng@zju.edu.cn.

PMID: 34265644
DOI: 10.1016/j.foodchem.2021.130542

Abstract

The Zein-Lecithin-Epigallocatechin gallate (EGCG) complex nanoparticles were fabricated by anti-solvent coprecipitation method. The Zein-Lecithin (Z-L) nanocomplexes exhibited great encapsulation efficiency of 68.5% for EGCG, and the encapsulated EGCG still had good antioxidative capacity. The cumulative release of EGCG in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) were 19% and 92%, respectively, and the release was closest to Fick release in SGF and First release in SIF. Fluorescence spectroscopy (FL), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) experiments revealed that the EGCG was successfully encapsulated by Z-L nanocomplexes through electrostatic, hydrophobic and hydrogen bonding interactions. The Zein-Lecithin-EGCG complex nanoparticles exhibited excellent stability and great sustained-release performance, which will be the alternative for potential application in the food industry.

Keywords: EGCG; Encapsulation; Lecithin; Stability; Sustained-release; Zein.

MeSH terms

Catechin / analogs & derivatives
Delayed-Action Preparations
Digestion
Lecithins
Nanoparticles*
Particle Size
Zein*

Substances

Delayed-Action Preparations
Lecithins
Catechin
Zein
epigallocatechin gallate