Simultaneous measurements of single gamma ray of 131I and annihilation radiation of 18F with Compton PET hybrid camera

Kenichiro Ogane; Mizuki Uenomachi; Kenji Shimazoe; Miwako Takahashi; Hiroyuki Takahashi; Yasuyuki Seto; Toshimitsu Momose

doi:10.1016/j.apradiso.2021.109864

Simultaneous measurements of single gamma ray of ¹³¹I and annihilation radiation of ¹⁸F with Compton PET hybrid camera

Appl Radiat Isot. 2021 Oct:176:109864. doi: 10.1016/j.apradiso.2021.109864. Epub 2021 Jul 10.

Authors

Kenichiro Ogane¹, Mizuki Uenomachi², Kenji Shimazoe³, Miwako Takahashi⁴, Hiroyuki Takahashi⁵, Yasuyuki Seto⁶, Toshimitsu Momose⁷

Affiliations

¹ Department of Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan; Department of Nuclear Medicine, International University of Health and Welfare, 1-4-3, Mita, Minato-ku, Tokyo, Japan. Electronic address: ken_ken_snow@iuhw.ac.jp.
² Department of Nuclear Engineering and Management, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan.
³ Department of Bioengineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan.
⁴ Department of Advanced Nuclear Medicine Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1, Anagawa, Inege-ku, Chiba, Japan.
⁵ Institute of Engineering Innovation, School of Engineering, The University of Tokyo, 2-11-16, Yayoi, Bunkyo-ku, Tokyo, Japan.
⁶ Department of Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan.
⁷ Department of Nuclear Medicine, International University of Health and Welfare, 1-4-3, Mita, Minato-ku, Tokyo, Japan.

PMID: 34265566
DOI: 10.1016/j.apradiso.2021.109864

Abstract

In internal 131I therapy for thyroid cancer, a decision to continue treatment is made by comparing 131I scintigraphy and [18F]FDG-PET. However, with current SPECT and PET systems, simultaneous imaging of diagnostic PET nuclides and therapeutic 131I nuclides has not been achieved so far. Therefore, we demonstrated that the recently developed Compton PET hybrid camera with Ce:Gd3(Al,Ga)5O12 (GAGG)- Silicon Photomultiplier(SiPM) scintillation detectors can be used to simultaneously image 131I Compton image and 18F PET image.

Keywords: Compton camera; Positron emission tomography; Radioactive iodine treatment; Theranostics; Thyroid cancer.

MeSH terms

Fluorine Radioisotopes / analysis*
Gamma Rays*
Humans
Iodine Radioisotopes / analysis*
Scintillation Counting / methods
Thyroid Neoplasms / radiotherapy

Substances

Fluorine Radioisotopes
Iodine Radioisotopes
Iodine-131
Fluorine-18