An aberrant inflammatory response in severe COVID-19

Miriam Merad; Aruna Subramanian; Taia T Wang

doi:10.1016/j.chom.2021.06.018

An aberrant inflammatory response in severe COVID-19

Cell Host Microbe. 2021 Jul 14;29(7):1043-1047. doi: 10.1016/j.chom.2021.06.018.

Authors

Miriam Merad¹, Aruna Subramanian², Taia T Wang³

Affiliations

¹ The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
² Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.
³ Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA; Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA. Electronic address: taiawang@stanford.edu.

Abstract

Severe COVID-19 arises from the convergence of inadequate pre-existing immunity and a host response that damages, rather than repairs, tissues. We outline clinical presentations of COVID-19 that are likely driven by dysregulated host immunity, discuss potential mechanisms underlying pathological responses, and highlight important areas for basic research on this topic.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

COVID-19 / immunology*
COVID-19 / pathology
Host Microbial Interactions / immunology*
Humans
Immunity
Immunocompromised Host
Inflammation / immunology*
SARS-CoV-2 / immunology

Abstract

Publication types

MeSH terms

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