Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives

Peng Huang; Shaomi Zhu; Xin Liang; Qinxiu Zhang; Xiaohong Luo; Chi Liu; Linjiang Song

doi:10.2147/CMAR.S314502

Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives

Cancer Manag Res. 2021 Jul 5:13:5317-5336. doi: 10.2147/CMAR.S314502. eCollection 2021.

Authors

Peng Huang¹, Shaomi Zhu¹, Xin Liang¹, Qinxiu Zhang¹, Xiaohong Luo¹, Chi Liu¹, Linjiang Song¹

Affiliation

¹ Reproductive & Women-Children Hospital, School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, People's Republic of China.

Abstract

Cancer cells exhibit distinct metabolic characteristics that employ glycolysis to provide energy and intermediary metabolites. This aberrant metabolic phenotype favors cancer progression. LncRNAs are transcripts longer than 200 nucleotides that do not encode proteins. LncRNAs contribute to cancer progression and therapeutic resistance and affect aerobic glycolysis via multiple mechanisms, including modulating glycolytic transporters and enzymes. Further, dysregulated signaling pathways are vital for glycolysis. In this review, we highlight regulatory mechanisms for lncRNAs in aerobic glycolysis that provide novel insights into cancer development. Moreover, a comprehensive understanding of the regulatory mechanisms of lncRNAs in aerobic glycolysis can provide new strategies for clinical cancer management.

Keywords: cancer progression; glycolysis; lncRNA; signaling pathway.

Publication types

Review

Grants and funding

The work was supported by Foundation of Science and Technology Department of Sichuan Province (2020YJ0147); Foundation of “apricot grove scholar” of Chengdu University of Traditional Chinese Medicine (2019yky09); Postdoctoral Science Foundation of Chengdu University of Traditional Chinese Medicine (030054080).