Antimicrobial photodynamic and photobiomodulation adjuvant therapies for the treatment of perianal abscess

Photodiagnosis Photodyn Ther. 2021 Sep:35:102437. doi: 10.1016/j.pdpdt.2021.102437. Epub 2021 Jul 11.

Abstract

Although the treatment and management options for perianal abscess vary considerably, most cases require incision and drainage. Whatever the clinical approach selected, it is imperative to monitor patients to identify postoperative signs and symptoms which suggest treatment failure or further complications, such as sepsis, recurrent abscess, and fistula formation. Considering the debate on the role of postoperative antibiotic therapy for patients with perianal abscess and the significant discomfort caused by the infection, the present study aimed to report a clinical case in which antimicrobial photodynamic therapy (aPDT) and photobiomodulation therapy (PBMT) were used after incision and drainage of a simple perianal abscess. Within 5 days, there was no sign or symptom of both infection and inflammation, and after 3 months, no fistulous pathways or perianal collections were present. According to the current case report, the combination of aPDT and PBMT following incision and drainage of perianal abscess may be a smart strategy for infection resolution and prevention of late complications.

Keywords: Perianal abscess; Perianal fistula; Photobiomodulation; Photodynamic therapy.

Publication types

  • Case Reports

MeSH terms

  • Abscess / drug therapy
  • Anti-Bacterial Agents / therapeutic use
  • Anti-Infective Agents*
  • Anus Diseases* / drug therapy
  • Humans
  • Low-Level Light Therapy*
  • Photochemotherapy* / methods
  • Photosensitizing Agents
  • Rectal Fistula* / drug therapy

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Photosensitizing Agents