Redox-responsive magnetic nanovectors self-assembled from amphiphilic polymer and iron oxide nanoparticles for a remotely targeted delivery of paclitaxel

J Mater Chem B. 2021 Aug 4;9(30):6037-6043. doi: 10.1039/d1tb00991e.

Abstract

To reduce the side effect of paclitaxel and enhance accumulation at the tumor site, a novel redox-responsive nanovector with excellent biocompatibility based on disulfide-linked amphiphilic polymer and magnetic nanoparticle was prepared. The system would realize PTX release due to breakage of the disulfide bond when being targeted to the tumor site by the external magnetic field. The nanovector significantly improved endocytosis and enhanced accumulation at the tumor site, with an effective inhibition of tumor cells in vitro and in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Apoptosis / drug effects
  • Cell Survival / drug effects
  • Disulfides / chemistry
  • Drug Delivery Systems
  • Drug Screening Assays, Antitumor
  • Ferric Compounds / chemistry*
  • HeLa Cells
  • Humans
  • Magnetic Phenomena
  • Mice
  • Mice, Nude
  • Nanoparticles / chemistry*
  • Neoplasms, Experimental / drug therapy
  • Neoplasms, Experimental / metabolism
  • Neoplasms, Experimental / pathology
  • Oxidation-Reduction
  • Paclitaxel / chemistry
  • Paclitaxel / pharmacology*
  • Polymers / chemical synthesis
  • Polymers / chemistry*
  • Surface-Active Agents / chemical synthesis
  • Surface-Active Agents / chemistry*
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents, Phytogenic
  • Disulfides
  • Ferric Compounds
  • Polymers
  • Surface-Active Agents
  • ferric oxide
  • Paclitaxel