A Mutation of lips-6 in C. elegans

Sarah M Cohen; Henry H Le; Paul W Sternberg

doi:10.17912/micropub.biology.000419

A Mutation of lips-6 in C. elegans

MicroPubl Biol. 2021 Jul 9:2021:10.17912/micropub.biology.000419. doi: 10.17912/micropub.biology.000419. eCollection 2021.

Authors

Sarah M Cohen¹, Henry H Le², Paul W Sternberg¹

Affiliations

¹ Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
² Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.

Abstract

The lips-6 gene encodes a putative lipase that plays a role in adult starvation response through a pathway that is parallel to the dauer pathway in larval Caenorhabditis elegans worms. We created a mutation of lips-6 to study its effects on lifespan and the ascaroside profile. We found that lips-6 had a wild-type lifespan and a wild-type ascaroside profile. These results suggest that the lips-6 gene plays a minimal role in C. elegans lifespan biology and does not affect the ascaroside profile until it is specifically activated by starvation in adult worms.