Background: Lung cancer has the highest mortality in China. Different treatments are of great significance to the prognosis of patients. By comparing stage Ia non-small cell lung cancer (NSCLC) patients' survival rates for ablation and for sub-lobectomy, we studied the difference in the effects of the two treatments on patient prognosis.
Methods: Using the Surveillance, Epidemiology, and End Results (SEER) database, we screened eligible patients with stage Ia NSCLC from January 2004 to December 2015. Then, 228 patients treated with ablation and 228 patients treated with sub-lobotomy were then selected based on propensity score matching. After stratification, matching, and adjustment the Kaplan-Meier analysis was performed to compare the overall survival rates of patients treated with the two procedures.
Results: The Kaplan-Meier survival analysis showed that there is a significant difference between the ablation group and the sub-lobectomy group (P<0.05). In the univarlable analysis, the hazard ratio (HR) of sub-lobotomy group was 0.571 (95%CI: 0.455-0.717) compared with the ablation group. Patients treated with sub-lobectomy had a 0.571 times greater risk of adverse outcomes than those treated with ablation. In the multivariable analysis, the HR for sub-lobectomy group was 0.605 (95%CI: 0.477-0.766) compared with the ablation group. Patients treated with sub-lobectomy had a 0.605 time greater risk of adverse outcomes than those treated with ablation. The results suggested that the overall survival rate of patients with stage Ia NSCLC treated with sub-lobotomy was higher than that of patients treated with ablation.
Conclusions: This study suggests that there is a significant difference in overall survival of stage Ia NSCLC patients treated with ablation and with sub-lobotomy. Patients treated with sub-lobotomy for stage Ia NSCLC had higher overall survival than those treated with ablation.
【中文题目：消融术和亚肺叶切除术治疗Ia期非小细胞肺癌患者疗效的对比】 【中文摘要：背景与目的 肺癌是我国死亡率最高的肿瘤，不同治疗方式对于患者预后的影响具有重要的意义。通过比较消融术和亚肺叶切除术治疗Ia期非小细胞肺癌（non-small cell lung cancer, NSCLC）患者的生存期，分析该两种治疗方案对早期肺癌患者预后生存的不同影响。方法 运用美国国立癌症研究所监测、流行病学和结果数据库（The Surveillance, Epidemiology, and End Results, SEER），我们从2004年1月-2015年12月之间筛选了符合条件的Ia期NSCLC患者进行研究。通过倾向性评分匹配，筛选出228例采用消融术治疗和228例采用亚肺叶切除术治疗的Ia期NSCLC的患者，并进行Kaplan-Meier生存曲线分析。比较Ia期NSCLC患者在经过匹配和调整后接受不同治疗方式的总生存率情况。结果 Kaplan-Meier生存曲线分析消融组和亚肺叶切除术组之间的生存曲线存在明显差异（P<0.05）。单因素分析中，与消融组相比，亚肺叶切除术的风险比（hazard ratio, HR）为0.571（95%CI: 0.455-0.717），即采用亚肺叶切除术治疗的患者产生的不良结局风险是消融术的0.571倍；在多因素分析中，亚肺叶切除术的HR为0.605（95%CI: 0.477-0.766），即采用亚肺叶切除术治疗的患者产生的不良结局风险是消融术的0.605倍。以上结果均提示亚肺叶切除术治疗Ia期NSCLC患者的总生存率高于消融术。结论 使用消融术和亚肺叶切除术治疗的Ia期NSCLC患者的总生存率之间存在明显差异。采用亚肺叶切除术治疗Ia期NSCLC的患者总生存率明显高于消融术组。】 【中文关键词：消融术；亚肺叶切除术；肺肿瘤；总生存期】.
Keywords: Ablation; Lung neoplasms; Overall survival; Sub-lobotomy.