In this article, we address the disturbance/ uncertainty estimation of maritime autonomous surface ships (MASSs) with unknown internal dynamics, unknown external disturbances, and unknown input gains. In contrast to existing disturbance observers where some prior knowledge on kinetic model parameters such as the control input gains is available in advance, reduced- and full-order data-driven adaptive disturbance observers (DADOs) are proposed for estimating unknown input gains, as well as total disturbance composed of unknown internal dynamics and external disturbances. An advantage of the proposed DADOs is that the total disturbance and input gains can be simultaneously estimated with guaranteed convergence via data-driven adaption. We apply the proposed full-order DADO for the trajectory tracking control of an MASS without kinetic modeling and present a model-free trajectory tracking control law for the ship based on the DADO and a backstepping technique. We report the simulation results to substantiate the efficacy of the proposed DADO approach to model-free trajectory tracking control of an autonomous surface ship without knowing its dynamics.