Ten new nortriterpenes from Euphorbia resinifera and their anti-tomato yellow leaf curl virus activities

Ning-Dong Zhao; Yu-Lin Li; Yu Song; Bao-Jia Yang; Xiao Ding; Fang Gao; Jian Ye; Xiao-Jiang Hao; Yu Zhang; Shun-Lin Li

doi:10.1016/j.fitote.2021.104989

Ten new nortriterpenes from Euphorbia resinifera and their anti-tomato yellow leaf curl virus activities

Fitoterapia. 2021 Sep:153:104989. doi: 10.1016/j.fitote.2021.104989. Epub 2021 Jul 9.

Authors

Ning-Dong Zhao¹, Yu-Lin Li², Yu Song², Bao-Jia Yang², Xiao Ding², Fang Gao³, Jian Ye⁴, Xiao-Jiang Hao², Yu Zhang⁵, Shun-Lin Li⁶

Affiliations

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China; College of Chemistry and Engineering, Wenshan University, Wenshan 663000, PR China; College of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400044, PR China.
² State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China.
³ College of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400044, PR China.
⁴ State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China.
⁵ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: zhangyu@mail.kib.ac.cn.
⁶ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China. Electronic address: lisl@mail.kib.ac.cn.

PMID: 34252513
DOI: 10.1016/j.fitote.2021.104989

Abstract

Ten new nortriterpenes, euphorbiumrins A-J (1-10), together with three known analogues (11-13) were isolated from the latex of Euphorbia resinifera. Their structures were established on the basis of extensive spectroscopic analyses (IR, UV, HRESIMS, 1D and 2D NMR). Their inhibitions on tomato yellow leaf curl virus (TYLCV) were evaluated and compound 5 exhibited significant anti-TYLCV activity with an inhibition rate of 71.7% at concentration of 40 μg/mL.

Keywords: Anti-TYLCV; Euphorbia resinifera; Nortriterpenes.

MeSH terms

Begomovirus / drug effects*
China
Euphorbia / chemistry*
Latex / chemistry
Molecular Structure
Nicotiana / virology
Phytochemicals / isolation & purification
Phytochemicals / pharmacology
Plant Diseases / prevention & control*
Plant Diseases / virology
Triterpenes / isolation & purification
Triterpenes / pharmacology*

Substances

Latex
Phytochemicals
Triterpenes

Supplementary concepts

Tomato yellow leaf curl virus