Comparison of conventional methods with commercially available topical hemostat surgical snow (oxidized cellulose) for achieving hemostasis in canine model of partial splenectomy

Pol J Vet Sci. 2021 Jun;24(2):281-286. doi: 10.24425/pjvs.2021.137663.

Abstract

Spleen is highly vascularized organ and bleeding control during partial splenectomy is a big challenge. In this study conventional methods of electrocautery, absorbable suturing and advance methods of topical hemostat Surgicel® were compared to control bleeding during partial splenec- tomy. Twelve healthy dogs (n=4) were divided in A, B and C groups. After partial splenectomy Surgicel®, electrocautery and absorbable horizontal mattress sutures were used to control hemor- rhages in group A, B and C respectively. Bleeding time and loss of blood volume was evaluated during surgery. In addition, blood samples were taken on day 0 pre-surgery and on days 3, 10 and 17 post-surgery to evaluate changes in biochemical parameters after the application of dif- ferent hemostatic techniques. Ultrasonography was also performed at alternative days to check any gross changes in the spleen. Dogs in group A showed minimum bleeding time and loss of blood volume as compared to group B and C. Drop in red blood cells count was compared be- tween group A, B and C showing significant change (p≤0.05) at day 3, 10 and 17, while a sig- nificant decline in hemoglobin was found in group C followed by groups B and A at 3rd and 10th day. There was no difference between platelet counts in various groups. Ultrasonography showed no significant changes in the spleen parenchyma. It was concluded that Surgicel® was an effective material for controlling hemorrhage in veterinary patients.

Keywords: Surgicel®; bleeding time; dogs; electrocautery; hematobiochemical parameters; partial splenectomy.

MeSH terms

  • Animals
  • Blood Loss, Surgical / prevention & control
  • Blood Loss, Surgical / veterinary*
  • Cellulose, Oxidized / administration & dosage
  • Cellulose, Oxidized / pharmacology*
  • Dog Diseases
  • Dogs
  • Hemostasis, Surgical / methods
  • Hemostasis, Surgical / veterinary*
  • Hemostatics / administration & dosage
  • Hemostatics / pharmacology
  • Spleen / surgery*
  • Splenectomy / methods
  • Splenectomy / veterinary*

Substances

  • Cellulose, Oxidized
  • Hemostatics
  • Surgicel