S1P signaling, its interactions and cross-talks with other partners and therapeutic importance in colorectal cancer

Real Sumayya Abdul Sattar; Mamta P Sumi; Nimisha; Apurva; Arun Kumar; Abhay Kumar Sharma; Ejaj Ahmad; Asgar Ali; Bhawna Mahajan; Sundeep Singh Saluja

doi:10.1016/j.cellsig.2021.110080

S1P signaling, its interactions and cross-talks with other partners and therapeutic importance in colorectal cancer

Cell Signal. 2021 Oct:86:110080. doi: 10.1016/j.cellsig.2021.110080. Epub 2021 Jul 7.

Authors

Affiliations

¹ Central Molecular Laboratory, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), New Delhi, India.
² Department of Biochemistry, All India Institute of Medical Science (AIIMS), Patna, Bihar, India.
³ Central Molecular Laboratory, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), New Delhi, India; Department of Biochemistry, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), New Delhi, India.
⁴ Central Molecular Laboratory, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), New Delhi, India; Department of GI Surgery, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research (GIPMER), New Delhi, India. Electronic address: sundeepsaluja@yahoo.co.in.

PMID: 34245863
DOI: 10.1016/j.cellsig.2021.110080

Abstract

Sphingosine-1-Phosphate (S1P) plays an important role in normal physiology, inflammation, initiation and progression of cancer. Deregulation of S1P signaling causes aberrant proliferation, affects survival, leads to angiogenesis and metastasis. Sphingolipid rheostat is crucial for cellular homeostasis. Discrepancy in sphingolipid metabolism is linked to cancer and drug insensitivity. Owing to these diverse functions and being a potent mediator of tumor growth, S1P signaling might be a suitable candidate for anti-tumor therapy or combination therapy. In this review, with a focus on colorectal cancer we have summarized the interacting partners of S1P signaling pathway, its therapeutic approaches along with the contribution of S1P signaling to various cancer hallmarks.

Keywords: CRC; Cancer hallmarks; Deregulation; S1P signaling; Therapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Colorectal Neoplasms*
Humans
Lysophospholipids* / metabolism
Signal Transduction
Sphingosine / analogs & derivatives
Sphingosine / metabolism

Substances

Lysophospholipids
sphingosine 1-phosphate
Sphingosine