A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Qianwen Liu; Amin Zhang; Ruhao Wang; Qian Zhang; Daxiang Cui

doi:10.1007/s40820-021-00674-8

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Nanomicro Lett. 2021 Jul 9;13(1):154. doi: 10.1007/s40820-021-00674-8.

Authors

Qianwen Liu^{1

2}, Amin Zhang^{3

4}, Ruhao Wang^{1

2}, Qian Zhang^{1

2}, Daxiang Cui^{5

6}

Affiliations

¹ Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan RD, Shanghai, 200240, People's Republic of China.
² Institute of Nano Biomedicine, National Engineering Research Center for Nanotechnology, 28 Jiangchuan Easternroad, Shanghai, 200241, People's Republic of China.
³ Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan RD, Shanghai, 200240, People's Republic of China. zhangamin@sjtu.edu.cn.
⁴ Institute of Nano Biomedicine, National Engineering Research Center for Nanotechnology, 28 Jiangchuan Easternroad, Shanghai, 200241, People's Republic of China. zhangamin@sjtu.edu.cn.
⁵ Institute of Nano Biomedicine and Engineering, Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan RD, Shanghai, 200240, People's Republic of China. dxcui@sjtu.edu.cn.
⁶ Institute of Nano Biomedicine, National Engineering Research Center for Nanotechnology, 28 Jiangchuan Easternroad, Shanghai, 200241, People's Republic of China. dxcui@sjtu.edu.cn.

Abstract

Since the ferromagnetic (Fe₃O₄) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress in nanozymes has been made with deep investigation of diverse nanozymes and rapid development of related nanotechnologies. As promising alternatives for natural enzymes, nanozymes have broadened the way toward clinical medicine, food safety, environmental monitoring, and chemical production. The past decade has witnessed the rapid development of metal- and metal oxide-based nanozymes owing to their remarkable physicochemical properties in parallel with low cost, high stability, and easy storage. It is widely known that the deep study of catalytic activities and mechanism sheds significant influence on the applications of nanozymes. This review digs into the characteristics and intrinsic properties of metal- and metal oxide-based nanozymes, especially emphasizing their catalytic mechanism and recent applications in biological analysis, relieving inflammation, antibacterial, and cancer therapy. We also conclude the present challenges and provide insights into the future research of nanozymes constituted of metal and metal oxide nanomaterials.

Keywords: Applications; Catalytic mechanism; Intrinsic properties; Metal- and metal oxide-based nanozymes.

Publication types

Review