Clinical Statistical Analysis with Comparison between Pelvic and Non-pelvic Chondrosarcoma

Sayed Abdulla Jami; Shi Jiandang; Brotendu Shekhar Roy; Zhanwen Zhou; Liu Chang Hao

doi:10.5001/omj.2021.65

Clinical Statistical Analysis with Comparison between Pelvic and Non-pelvic Chondrosarcoma

Oman Med J. 2021 May 31;36(3):e271. doi: 10.5001/omj.2021.65. eCollection 2021 May.

Authors

Sayed Abdulla Jami¹, Shi Jiandang¹, Brotendu Shekhar Roy², Zhanwen Zhou¹, Liu Chang Hao¹

Affiliations

¹ Department of Spinal Surgery, General Hospital of Ningxia Medical University, Ningxia, People's Republic of China.
² Department of Clinical Medicine, First affiliated hospital of Nanchang University, Jiangxi, People's Republic of China.

Abstract

Objectives: Chondrosarcomas are rare tumors with a variable biological characteristic. Their treatment clinically and surgically is controversial. Analysis of the clinical statistics and prognostic factors of pelvic chondrosarcoma provides a reference for clinical diagnosis and treatment.

Methods: A total of 73 cases of chondrosarcoma were collected, including 24 pelvic samples, from 2008 to 2017 from the hospital database and divided into two groups: pelvic chondrosarcoma and non-pelvic chondrosarcoma. The clinical characteristics and prognostic factors of pelvic chondrosarcoma were analyzed using different statistical methods.

Results: Among the 24 pelvic chondrosarcoma patients, the ratio of male to female was 1.4:1, and the median age was 43.5 years. According to the classification proposed by Enneking, there were five grade I, 14 grade II, and five grade III. Histological grading of chondrosarcoma was grade I in one case, II in 15 cases, and III in eight cases. The histological type was 17 conventional, three dedifferentiated, two secondary, one myxoid, and one mesenchymal. The overall survival rates for 24 cases at three, five, and 10 years were 82.2±8.1%, 77.3±8.9%, and 52.4±12.1%, respectively. The local recurrence rate of pelvic chondrosarcoma after surgical resection (83.3%) was significantly higher than that of other sites (34.7%), and the difference was statistically significant (p < 0.001). The final proportion of amputation rate (50.0%) was also higher than other parts (20.4%), with a statistically significant difference (p = 0.010). The total survival of the two groups was not significantly different (p = 0.216).

Conclusions: Chondrosarcoma of bone generally has an excellent prognosis when optimally diagnosed and treated by an experienced team of specialists. Pelvic chondrosarcoma has a higher local recurrence rate than the other sites and tends to result in amputation. Early local recurrence after surgery indicates a poor prognosis.

Keywords: Bone Neoplasms; Chondrosarcoma; Neoplasm Recurrence, Local; Prognosis.

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