Comprehensive Bibliometric Analysis of the Kynurenine Pathway in Mood Disorders: Focus on Gut Microbiota Research

Xiuqing Zhu; Jinqing Hu; Shuhua Deng; Yaqian Tan; Chang Qiu; Ming Zhang; Xiaojia Ni; Haoyang Lu; Zhanzhang Wang; Lu Li; Yayan Luo; Shanqing Huang; Tao Xiao; Shujing Liu; Xiaolin Li; Dewei Shang; Yuguan Wen

doi:10.3389/fphar.2021.687757

Comprehensive Bibliometric Analysis of the Kynurenine Pathway in Mood Disorders: Focus on Gut Microbiota Research

Front Pharmacol. 2021 Jun 22:12:687757. doi: 10.3389/fphar.2021.687757. eCollection 2021.

Authors

Xiuqing Zhu^{1

2}, Jinqing Hu^{1

2}, Shuhua Deng^{1

2}, Yaqian Tan^{1

2}, Chang Qiu^{1

2}, Ming Zhang^{1

2}, Xiaojia Ni^{1

2}, Haoyang Lu^{1

2}, Zhanzhang Wang^{1

2}, Lu Li^{1

2}, Yayan Luo^{2

3}, Shanqing Huang¹, Tao Xiao¹, Shujing Liu¹, Xiaolin Li¹, Dewei Shang^{1

2}, Yuguan Wen^{1

2}

Affiliations

¹ Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
² Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China.
³ Institute of Neuropsychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.

Abstract

Background: Emerging evidence implicates the dysregulated kynurenine pathway (KP), an immune-inflammatory pathway, in the pathophysiology of mood disorders (MD), including depression and bipolar disorder characterized by a low-grade chronic pro-inflammatory state. The metabolites of the KP, an important part of the microbiota-gut-brain axis, serve as immune system modulators linking the gut microbiota (GM) with the host central nervous system. Aim: This bibliometric analysis aimed to provide a first glimpse into the KP in MD, with a focus on GM research in this field, to guide future research and promote the development of this field. Methods: Publications relating to the KP in MD between the years 2000 and 2020 were retrieved from the Scopus and Web of Science Core Collection (WoSCC), and analyzed in CiteSpace (5.7 R5W), biblioshiny (using R-Studio), and VOSviewer (1.6.16). Results: In total, 1,064 and 948 documents were extracted from the Scopus and WoSCC databases, respectively. The publications have shown rapid growth since 2006, partly owing to the largest research hotspot appearing since then, "quinolinic acid." All the top five most relevant journals were in the neuropsychiatry field, such as Brain Behavior and Immunity. The United States and Innsbruck Medical University were the most influential country and institute, respectively. Journal co-citation analysis showed a strong tendency toward co-citation of research in the psychiatry field. Reference co-citation analysis revealed that the top four most important research focuses were "kynurenine pathway," "psychoneuroimmunology," "indoleamine 2,3-dioxygenase," and "proinflammatory cytokines," and the most recent focus was "gut-brain axis," thus indicating the role of the KP in bridging the GM and the host immune system, and together reflecting the field's research foundations. Overlap analysis between the thematic map of keywords and the keyword burst analysis revealed that the topics "Alzheimer's disease," "prefrontal cortex," and "acid," were research frontiers. Conclusion: This comprehensive bibliometric study provides an updated perspective on research associated with the KP in MD, with a focus on the current status of GM research in this field. This perspective may benefit researchers in choosing suitable journals and collaborators, and aid in the further understanding of the field's hotspots and frontiers, thus facilitating future research.

Keywords: bibliometric analysis; bipolar disorder; depression; gut microbiota; immune system; kynurenine pathway; microbiota-gut-brain axis; mood disorders.