6,9-Dihydroxytetrangulol, a novel angucyclinone antibiotic accumulated in kiqO gene disruptant in the biosynthesis of kinanthraquinone

J Antibiot (Tokyo). 2021 Sep;74(9):593-595. doi: 10.1038/s41429-021-00442-1. Epub 2021 Jul 7.

Abstract

A novel angucyclinone, 6,9-dihydroxytetrangulol, was isolated from Streptomyces lividans TK23 transformed with a kinanthraquinone biosynthetic gene cluster in which the kiqO gene was disrupted. The chemical structure was elucidated by spectroscopic analyses. It showed significant antibacterial activities with an IC50 value of 1.9 μM against Staphylococcus aureus and moderate anticancer activities against HL-60 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthraquinones / chemistry
  • Anthraquinones / isolation & purification
  • Anthraquinones / pharmacology*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • HL-60 Cells
  • Humans
  • Inhibitory Concentration 50
  • Multigene Family
  • Staphylococcus aureus / drug effects
  • Streptomyces lividans / genetics
  • Streptomyces lividans / metabolism*

Substances

  • Anthraquinones
  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • angucyclinone