A garlic oil-based organo-hydrogel for use in pH-sensitive drug release

Duygu Alpaslan; Tulü Olak; Abdullah Turan; Tuba Ersen Dudu; Nahit Aktas

doi:10.1007/s11696-021-01760-2

A garlic oil-based organo-hydrogel for use in pH-sensitive drug release

Chem Zvesti. 2021;75(11):5759-5772. doi: 10.1007/s11696-021-01760-2. Epub 2021 Jul 2.

Authors

Duygu Alpaslan¹, Tulü Olak¹, Abdullah Turan², Tuba Ersen Dudu¹, Nahit Aktas^{1

3}

Affiliations

¹ Engineering Faculty, Department of Chemical Engineering, Campus, Van Yüzüncü Yil University, Van, 65080 Turkey.
² Science Faculty, Department of Molecular Biology and Genetic, Campus, Van Yüzüncü Yil University, Van, 65080 Turkey.
³ Faculty of Engineering, Department of Chemical Engineering, Kyrgyz-Turkish Manas University, Bishkek, Kyrgyz Republic.

Abstract

In this study, six different organo-hydrogels containing agar-glycerol (AG)-based garlic oil (GO) were synthesized using two different crosslinkers (N,N, methylenebisacrylamide (MBA), glutaraldehyde (GA)) to ensure the controlled release of ceftriaxone (Ce) and carboplatin (Cp). Synthesized organo-hydrogels were characterized by FT-IR. Afterward, swelling behaviors were investigated in DI, tap water, ethanol, acetone, ethanol/DI water (1:1), acetone/DI water (1:1) and gasoline environments and different pH. As a result of hemolysis, blood clotting and antioxidant analysis, organo-hydrogels have been shown to have blood compatibility and antioxidant properties. Ce and Cp release properties of the prepared organo-hydrogels were also determined. The highest Ce release rate was obtained to be 37.8% for p (AG-g-GO)³ at pH 8.0 after 7 days. However, the highest Cp release rate was found to be 95.4% for p (AG-g-GO)³ at pH 7.4 after 1 day.

Keywords: Agar; Carboplatin; Ceftriaxone; Garlic oil; Organo-hydrogel.