Biocompatible and photocrosslinkable poly(ethylene glycol)/keratin biocomposite hydrogels

Chenshu Wang; Lijuan Wang; Xiuzhen Wan; Xuefeng Jiang; Jiang Yuan

doi:10.1080/09205063.2021.1952384

Biocompatible and photocrosslinkable poly(ethylene glycol)/keratin biocomposite hydrogels

J Biomater Sci Polym Ed. 2021 Oct;32(15):1998-2008. doi: 10.1080/09205063.2021.1952384. Epub 2021 Jul 28.

Authors

Chenshu Wang¹, Lijuan Wang¹, Xiuzhen Wan¹, Xuefeng Jiang¹, Jiang Yuan¹

Affiliation

¹ Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, P. R. China.

PMID: 34228943
DOI: 10.1080/09205063.2021.1952384

Abstract

A biocompatible hydrogel is ideal for tissue engineering and regeneration. In this study, methacrylated keratin (KerMA) was synthesized for the first time and then blended with poly(ethylene glycol dimethacrylate) (PEGDMA) to form hydrogel through photocrosslinking. The chemical structure, gelation time, swelling behavior, hydrophilicity, cytotoxicity, and 3D printability of PEGDMA/KerMA hydrogels were characterized and exploited. The PEGDMA/KerMA hydrogels performed good cytocompatibility, providing potential applications for tissue engineering and regenerative medicine.

Keywords: Methacrylated keratin; PEGDMA; biocompatibility; hydrogel; photocrosslinking.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials*
Hydrogels
Keratins*
Polyethylene Glycols
Tissue Engineering

Substances

Biocompatible Materials
Hydrogels
Polyethylene Glycols
Keratins