Acquired thrombotic thrombocytopenic purpura with possible association with AstraZeneca-Oxford COVID-19 vaccine

Mona Al-Ahmad; Mona Al-Rasheed; Neveen Abo Bakr Shalaby

doi:10.1002/jha2.219

Acquired thrombotic thrombocytopenic purpura with possible association with AstraZeneca-Oxford COVID-19 vaccine

EJHaem. 2021 May 18;2(3):534-536. doi: 10.1002/jha2.219. eCollection 2021 Aug.

Authors

Mona Al-Ahmad^{1

2}, Mona Al-Rasheed³, Neveen Abo Bakr Shalaby³

Affiliations

¹ Microbiology Department Faculty of Medicine Kuwait University Kuwait Kuwait.
² Al Rashed Allergy Centre Ministry of Health Kuwait.
³ Hematology Unit Department of Medicine Al Adnan Hospital Ministry of Health Kuwait.

Abstract

Acquired thrombotic thrombocytopenic purpura is characterized by the microvascular aggregation of platelets and microangiopathic hemolytic anemia causing ischemia of multiple organs including the brain mainly and less likely the kidney and the heart. The disease is caused by severe reduction in the activity of ADAMTS 13 due to presence of inhibitory antibodies.

Keywords: TTP; covid‐19; thrombocytopenia; vaccines.

Publication types

Case Reports