Abstract
A chlorine e6 (Ce6) and curcumin (Cur) based self-delivery nanomedicine (CeCu) is prepared for chemotherapy sensitized photodynamic therapy (PDT). The chemotherapeutic agent of Cur could inhibit the TrxR activity to destroy the cellular ROS-defence system for enhanced PDT, which provides synergistic effects for tumor precision therapy in consideration of the unfavorable tumor microenvironments.
MeSH terms
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Animals
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Cell Line
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Cell Survival / drug effects
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Chlorophyllides
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Curcumin / chemistry
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Curcumin / metabolism
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Curcumin / pharmacology
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Humans
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Mice
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Microscopy, Confocal
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Nanomedicine*
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Neoplasms / drug therapy
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Neoplasms / pathology
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Photochemotherapy / methods*
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / pharmacology
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Photosensitizing Agents / therapeutic use
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Porphyrins / chemistry
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Porphyrins / metabolism
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Porphyrins / pharmacology
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Reactive Oxygen Species / metabolism
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Thioredoxin-Disulfide Reductase / antagonists & inhibitors
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Thioredoxin-Disulfide Reductase / metabolism
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Transplantation, Heterologous
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Tumor Microenvironment
Substances
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Chlorophyllides
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Photosensitizing Agents
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Porphyrins
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Reactive Oxygen Species
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phytochlorin
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Thioredoxin-Disulfide Reductase
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Curcumin