Oral and parenteral antibiotic use in Norwegian nursing homes: are primary care institutions becoming our new local hospitals?

Nicolay Jonassen Harbin; Jon Birger Haug; Maria Romøren; Morten Lindbæk

doi:10.1093/jacamr/dlaa093

Oral and parenteral antibiotic use in Norwegian nursing homes: are primary care institutions becoming our new local hospitals?

JAC Antimicrob Resist. 2020 Oct 29;2(4):dlaa093. doi: 10.1093/jacamr/dlaa093. eCollection 2020 Dec.

Authors

Nicolay Jonassen Harbin, Jon Birger Haug¹, Maria Romøren², Morten Lindbæk³

Affiliations

¹ Department of Infection Control, Østfold Health Trust, Kalnes, Norway.
² Centre for Medical Ethics, Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway.
³ Antibiotic Center for Primary Care, Department of General Practice, Institute of Health and Society, University of Oslo, Oslo, Norway.

Abstract

Background: Norwegian nursing homes (NHs) have over the last 10 years increasingly applied the use of parenteral treatment, which in turn allows more broad-spectrum use of antibiotics. Previous studies from Norwegian NHs have for the most part not described parenteral formulations.

Objectives: To describe systemic antibiotic use in Norwegian NHs.

Methods: Thirty-seven NHs in the county of Østfold, Norway, were invited to participate in this retrospective cross-sectional study. Associated pharmacies provided sales data for systemic antibiotic use for the participating NHs for 1 year (October 2015 to October 2016). General institutional characteristics were collected through a questionnaire.

Results: Thirty-four NHs participated in the study. Mean use of antibiotics was 10.0 DDD/100 bed days (range 0.6-30.9 DDD/100 bed days). Oral antibiotics accounted for 83% and parenteral antibiotics for 17% of the total antibiotic use. Of parenteral antibiotics, ampicillin was most used (31.1%) followed by cefotaxime (17.7%) and penicillin G (16.6%). The proportion of antibiotics compliant with guideline recommendations was 60%. Being a short-term NH was associated with increased antibiotic use, with an unstandardized coefficient of 13.1 (95% CI 4.2-21.9; P = 0.005).

Conclusions: We found a high level of total and parenteral antibiotic use compared with previous studies from Norwegian NHs. Data showed wide variations in total antibiotic use and that only a moderate proportion of the antibiotic use was considered guideline compliant. This highlights the necessity of further implementation strategies regarding the national guidelines for antibiotic use in NHs.