Rebound peripheral blastosis with subsequent remission during remission induction in a patient with acute promyelocytic leukemia

Cancer. 1988 Feb 15;61(4):650-3. doi: 10.1002/1097-0142(19880215)61:4<650::aid-cncr2820610405>3.0.co;2-9.

Abstract

A patient with acute promyelocytic leukemia manifested peripheral blastosis with 50% peripheral blasts and an absolute blast count of 10,000/microliter 2 weeks after the start of induction chemotherapy. The subsequent disappearance of the peripheral and marrow blasts without further chemotherapy was noticed, and complete remission was achieved on day 25 of chemotherapy. The histologic and clinical implications of this phenomenon are discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Bone Marrow / pathology
  • Cytarabine / administration & dosage
  • Female
  • Follow-Up Studies
  • Hematopoietic Stem Cells / drug effects*
  • Humans
  • Leukemia, Myeloid, Acute / blood
  • Leukemia, Myeloid, Acute / drug therapy*
  • Leukemia, Myeloid, Acute / pathology
  • Prednisone / administration & dosage
  • Vincristine / administration & dosage

Substances

  • Cytarabine
  • Vincristine
  • Prednisone

Supplementary concepts

  • OAP protocol