Controlled Release of Curcumin from HPMC (Hydroxypropyl Methyl Cellulose) Co-Spray-Dried Materials

Jiao Zheng; Bo Wang; Jia Xiang; Zhengyu Yu

doi:10.1155/2021/7625585

Controlled Release of Curcumin from HPMC (Hydroxypropyl Methyl Cellulose) Co-Spray-Dried Materials

Bioinorg Chem Appl. 2021 Jun 15:2021:7625585. doi: 10.1155/2021/7625585. eCollection 2021.

Authors

Jiao Zheng¹, Bo Wang², Jia Xiang², Zhengyu Yu³

Affiliations

¹ Drug Clinical Trial Institution Department, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Hunan 410000, China.
² Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410000, China.
³ Faculty of Engneering and IT, University of Technology, Sydney, NSW 2007, Australia.

Abstract

In order to achieve the controlled release of curcumin, HPMC (hydroxypropyl methyl cellulose) was spray dried with curcumin and lactose. The spray-dried materials were pressed into tablets with a diameter of 8 mm, and their release characteristics in vitro were measured. In vitro experiments showed that the release of curcumin from the HPMC mixture was significantly slower due to the sustained-release property of HPMC as a typical excipient. The release profile of curcumin from the HPMC mixture was relatively stable for a controlled release. SEM images show that the HPMC co-spray-dried powders have crumpled surfaces due to the large molecular weight of HPMC. DSC, XRD, FTIR, N₂ adsorption, and TGA have been measured for the spray-dried curcumin materials. This work indicates that HPMC can be used as a controlled-release excipient for curcumin preparations.

Publication types

Retracted Publication