NLRC5: A Potential Target for Central Nervous System Disorders

Lu Zhang; Cui Jiao; Lingjuan Liu; Aiping Wang; Li Tang; Yi Ren; Peng Huang; Jie Xu; Dingan Mao; Liqun Liu

doi:10.3389/fimmu.2021.704989

NLRC5: A Potential Target for Central Nervous System Disorders

Front Immunol. 2021 Jun 18:12:704989. doi: 10.3389/fimmu.2021.704989. eCollection 2021.

Authors

Lu Zhang^{1

2}, Cui Jiao^{1

2}, Lingjuan Liu^{1

2}, Aiping Wang^{1

2}, Li Tang^{1

2}, Yi Ren^{1

2}, Peng Huang^{1

2}, Jie Xu^{1

2}, Dingan Mao^{1

2}, Liqun Liu^{1

2}

Affiliations

¹ Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
² Children's Brain Development and Brain Injury Research Office, The Second Xiangya Hospital, Central South University, Changsha, China.

Abstract

Nucleotide oligomerization domain-like receptors (NLRs), a class of pattern recognition receptors, participate in the host's first line of defense against invading pathogenic microorganisms. NLR family caspase recruitment domain containing 5 (NLRC5) is the largest member of the NLR family and has been shown to play an important role in inflammatory processes, angiogenesis, immunity, and apoptosis by regulating the nuclear factor-κB, type I interferon, and inflammasome signaling pathways, as well as the expression of major histocompatibility complex I genes. Recent studies have found that NLRC5 is also associated with neuronal development and central nervous system (CNS) diseases, such as CNS infection, cerebral ischemia/reperfusion injury, glioma, multiple sclerosis, and epilepsy. This review summarizes the research progress in the structure, expression, and biological characteristics of NLRC5 and its relationship with the CNS.

Keywords: NLRC5; central nervous system; development; disease; pattern recognition receptor.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Central Nervous System Diseases / immunology*
Central Nervous System Diseases / therapy
Humans
Interferon Type I / immunology
Intracellular Signaling Peptides and Proteins / immunology*
NF-kappa B / immunology
Neurons / immunology

Substances

Interferon Type I
Intracellular Signaling Peptides and Proteins
NF-kappa B
NLRC5 protein, human