Role of Vaginal Microbiota Dysbiosis in Gynecological Diseases and the Potential Interventions

Yiwen Han; Zhaoxia Liu; Tingtao Chen

doi:10.3389/fmicb.2021.643422

Role of Vaginal Microbiota Dysbiosis in Gynecological Diseases and the Potential Interventions

Front Microbiol. 2021 Jun 18:12:643422. doi: 10.3389/fmicb.2021.643422. eCollection 2021.

Authors

Yiwen Han^{1

2}, Zhaoxia Liu¹, Tingtao Chen^{1

3}

Affiliations

¹ Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
² Queen Mary School, Nanchang University, Nanchang, China.
³ National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, China.

Abstract

Vaginal microbiota dysbiosis, characterized by the loss of Lactobacillus dominance and increase of microbial diversity, is closely related to gynecological diseases; thus, intervention on microbiota composition is significant and promising in the treatment of gynecological diseases. Currently, antibiotics and/or probiotics are the mainstay of treatment, which show favorable therapeutic effects but also bring problems such as drug resistance and high recurrence. In this review, we discuss the role of vaginal microbiota dysbiosis in various gynecological infectious and non-infectious diseases, as well as the current and potential interventions.

Keywords: Lactobacillus; antibiotics; bacterial vaginitis; gynecological diseases; vaginal microbiota transplantation.

Publication types

Review