New-Onset Postoperative Seizures in Patients With Diffuse Gliomas: A Risk Assessment Analysis

Lianwang Li; Guanzhang Li; Shengyu Fang; Kenan Zhang; Ruoyu Huang; Yinyan Wang; Chuanbao Zhang; Yiming Li; Wei Zhang; Zhong Zhang; Qiang Jin; Dabiao Zhou; Xing Fan; Tao Jiang

doi:10.3389/fneur.2021.682535

New-Onset Postoperative Seizures in Patients With Diffuse Gliomas: A Risk Assessment Analysis

Front Neurol. 2021 Jun 18:12:682535. doi: 10.3389/fneur.2021.682535. eCollection 2021.

Authors

Lianwang Li¹, Guanzhang Li¹, Shengyu Fang¹, Kenan Zhang¹, Ruoyu Huang¹, Yinyan Wang², Chuanbao Zhang², Yiming Li², Wei Zhang², Zhong Zhang², Qiang Jin², Dabiao Zhou², Xing Fan^{1

2}, Tao Jiang^{1

2

3}

Affiliations

¹ Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
² Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
³ Research Units of Accurate Diagnosis and Treatment of Brain Tumors and Translational Medicine, Chinese Academy of Medical Sciences, Beijing, China.

Abstract

Background: Glioma-related epilepsy (GRE) is the most common presenting sign of patients with diffuse glioma. According to clinical experience, new-onset postoperative seizures can be observed even in patients without preoperative GRE. The current study mainly aimed to explore the risk factors of new-onset postoperative seizures in those patients. In addition, the prognostic value of new-onset postoperative seizures was also discussed. Methods: Data of 313 patients without GRE were retrospectively reviewed. Chi-square test or Fisher's exact test were first performed to compare categorical variables between patients with new-onset postoperative seizures and those without. Subsequently, binary logistic regression analysis was conduct to further assess risk factors of new-onset postoperative seizures. Kaplan-Meier and Cox analysis were used to investigate the prognostic value of new-onset postoperative seizures for progression-free survival (PFS) and overall survival (OS). Results: Patients with low-grade tumors (p = 0.006), isocitrate dehydrogenase 1 (IDH1) mutation (p = 0.040) or low Ki-67 expression (p = 0.005) showed a higher incidence of new-onset postoperative seizures. IDH1 mutation was identified as the only independent predictor for new-onset postoperative seizures (OR, 2.075; 95% CI, 1.051-4.098; p = 0.035). Additionally, new-onset postoperative seizure occurrence was demonstrated as an independent predicter of prolonged OS (OR, 0.574; 95% CI, 0.335-0.983; p = 0.043), while younger age, gross total resection, low-grade and IDH1 mutation were independently correlated with prolonged OS and PFS. Conclusions: IDH1 mutation is an independent predictor for new-onset postoperative seizures in patients without preoperative GRE. Moreover, new-onset postoperative seizures can independently predict prolonged OS in those patients. The results of the current study can contribute to improving the individualized management of diffuse glioma.

Keywords: IDH1 mutation; diffuse glioma; new-onset postoperative seizures; overall survival; risk factors.