Systems Cytogenomics: Are We Ready Yet?

Ivan Y Iourov; Svetlana G Vorsanova; Yuri B Yurov

doi:10.2174/1389202922666210219112419

Systems Cytogenomics: Are We Ready Yet?

Curr Genomics. 2021 Feb;22(2):75-78. doi: 10.2174/1389202922666210219112419.

Authors

Ivan Y Iourov^{1

2

3}, Svetlana G Vorsanova^{1

2}, Yuri B Yurov^{1

2}

Affiliations

¹ Yurov's Laboratory of Molecular Genetics and Cytogenomics of the Brain, Mental Health Research Center, Moscow, 117152, Russia.
² Laboratory of Molecular Cytogenetics of Neuropsychiatric Diseases, Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University, Moscow, 125412, Russia.
³ Department of Medical Biological Disciplines, Belgorod State University, 308015, Belgorod, Russia.

Abstract

With the introduction of systems theory to genetics, numerous opportunities for genomic research have been identified. Consequences of DNA sequence variations are systematically evaluated using the network- or pathway-based analysis, a technological basis of systems biology or, more precisely, systems genomics. Despite comprehensive descriptions of advantages offered by systems genomic approaches, pathway-based analysis is uncommon in cytogenetic (cytogenomic) studies, i.e. genome analysis at the chromosomal level. Here, we would like to express our opinion that current cytogenomics benefits from the application of systems biology methodology. Accordingly, systems cytogenomics appears to be a biomedical area requiring more attention than it actually receives.

Keywords: Cytogenomics; DNA sequence; chromosome; genome; pathway; systems biology.