Ameliorative property of Sesbania grandiflora on carbohydrate metabolic enzymes in the liver and kidney of streptozotocin-induced diabetic rats

Chandrabose Sureka; Veerayan Elango; Sameer Al-Ghamdi; Khaled K Aldossari; Mohammed Alsaidan; Ayman Geddawy; Mohamed A Abdelaziz; Abubucker Peer Mohideen; Thiyagarajan Ramesh

doi:10.1016/j.sjbs.2021.05.002

Ameliorative property of Sesbania grandiflora on carbohydrate metabolic enzymes in the liver and kidney of streptozotocin-induced diabetic rats

Saudi J Biol Sci. 2021 Jul;28(7):3669-3677. doi: 10.1016/j.sjbs.2021.05.002. Epub 2021 May 8.

Authors

Affiliations

¹ Department of Siddha Medicine, Faculty of Science, Tamil University, Vakaiyur, Thanjavur 613 010, Tamil Nadu, India.
² Family and Community Medicine Department, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
³ Department of Dermatology, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
⁴ Department of Basic Medical Sciences, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
⁵ Department of Pharmacology, Faculty of Medicine, Minia University, 61511 Minia, Egypt.
⁶ Department of Medical Physiology, College of Medicine, Al-Azhar University, Cairo, Egypt.

Abstract

In diabetic condition, endogenous glucose synthesis will be elevated due to defect in the action of vital enzymes involved in carbohydrate metabolism, which is the main cause for hyperglycemia. The current study was designed to explore the anti-hyperglycemic efficacy of Sesbania grandiflora flower (SGF) extract by evaluating the concentration of C-peptide, insulin, glucose, glycosylated hemoglobin (HbA_1C), hemoglobin (Hb), glycogen and carbohydrate metabolic enzymes activities in diabetic rats. The study found to lower the level of glucose, HbA_1C and simultaneously ameliorated concentrations of C-peptide, insulin, hemoglobin (Hb), glycogen and carbohydrate metabolic enzymes activities in SGF treated (250 mg/kg body weight for 45 days) diabetic rats. Moreover, SGF administered diabetic rats showed diminished consumption of food and water at the same time improved body weight. The results obtained from the present study were compared with glibenclamide treated (600 µg/kg body weight) diabetic rats. SGF were supplemented to normal rats to rule out toxic effect of SGF, to explore any significant alteration in the above parameters. Hence, the results depict that SGF modulated the carbohydrate metabolic enzymes activities through ameliorating the secretion of insulin and diminishing the level of glucose concentration in STZ-induced diabetic rats by its bioactive compounds.

Keywords: Antihyperglycemic; Carbohydrate metabolic enzymes; Diabetic rats; Sesbania grandiflora flower.