Neurologic Manifestations of Noncongenital Zika Virus in Children

Aline Almeida Bentes; Ana Paula Correa Crispim; Paula Eillanny Silva Marinho; Eisler Cristiane Carvalho Viegas; Karina Soares Loutfi; Isabela Guedes; Sara Tavares Araujo; Alice Martins Alvarenga; Luciana Maria Campos E Silva; Marcele Almeida Santos; Aline Karla Batista; Pedro Paulo Alvarenga; Talitah Michel Sanchez Candiani; Erna Geessien Kroon; Roberta Maia de Castro Romanelli

doi:10.1016/j.jpeds.2021.06.074

Neurologic Manifestations of Noncongenital Zika Virus in Children

J Pediatr. 2021 Oct:237:298-301.e1. doi: 10.1016/j.jpeds.2021.06.074. Epub 2021 Jul 1.

Authors

Aline Almeida Bentes¹, Ana Paula Correa Crispim², Paula Eillanny Silva Marinho², Eisler Cristiane Carvalho Viegas³, Karina Soares Loutfi³, Isabela Guedes⁴, Sara Tavares Araujo⁴, Alice Martins Alvarenga³, Luciana Maria Campos E Silva⁴, Marcele Almeida Santos⁴, Aline Karla Batista⁵, Pedro Paulo Alvarenga⁴, Talitah Michel Sanchez Candiani³, Erna Geessien Kroon⁶, Roberta Maia de Castro Romanelli⁷

Affiliations

¹ Departamento de Pediatria, Universidade Federal de Minas Gerais, Minas Gerais, Brazil; Hospital Infantil João Paulo II, FHEMIG, Minas Gerais, Brazil.
² Laboratório de Vírus, Departamento de Microbiologia, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.
³ Hospital Infantil João Paulo II, FHEMIG, Minas Gerais, Brazil.
⁴ Faculdade de Medicina, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.
⁵ Faculdade de Enfermagem, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.
⁶ Laboratório de Vírus, Departamento de Microbiologia, Universidade Federal de Minas Gerais, Minas Gerais, Brazil. Electronic address: ernagkroon@gmail.com.
⁷ Departamento de Pediatria, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.

PMID: 34216632
DOI: 10.1016/j.jpeds.2021.06.074

Abstract

We evaluated neurologic complications following noncongenital Zika virus infection in 11 children who presented with central nervous system signs. Zika virus RNA was detected by real-time reverse transcription-polymerase chain reaction in cerebrospinal fluid. Approximately one-quarter of patients required antiepileptic medication in follow-up, and 2 children progressed to learning difficulties or developmental delay.

Keywords: Zika virus; children; encephalitis; meningitis.

MeSH terms

Anticonvulsants / therapeutic use
Brazil
Child
Child, Preschool
Developmental Disabilities / diagnosis
Developmental Disabilities / virology*
Electroencephalography
Female
Hospitalization
Humans
Infant
Learning Disabilities / diagnosis
Learning Disabilities / virology*
Male
Nervous System Diseases / diagnosis
Nervous System Diseases / virology*
Prospective Studies
Real-Time Polymerase Chain Reaction
Zika Virus / isolation & purification
Zika Virus Infection / complications*
Zika Virus Infection / diagnosis
Zika Virus Infection / psychology

Substances

Anticonvulsants