A delicate initiation: Lipolysis of lipid droplets fuels glioblastoma

Kailin Yang; Jeremy N Rich

doi:10.1016/j.molcel.2021.06.013

A delicate initiation: Lipolysis of lipid droplets fuels glioblastoma

Mol Cell. 2021 Jul 1;81(13):2686-2687. doi: 10.1016/j.molcel.2021.06.013.

Authors

Kailin Yang¹, Jeremy N Rich²

Affiliations

¹ Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, Ohio 44195, USA.
² University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, Pennsylvania 15213, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. Electronic address: drjeremyrich@gmail.com.

PMID: 34214442
DOI: 10.1016/j.molcel.2021.06.013

Abstract

Liu et al. (2021) demonstrate that CHKα2 is capable of promoting lipolysis of lipid droplets through mechanisms that require sequential steps of post-translational modifications after glucose deprivation. Intriguingly, the oxidation of fatty acids derived from lipid droplets is essential for the survival of tumor cells that informs clinical outcome among glioblastoma patients.

Publication types

Comment

MeSH terms

Fatty Acids / metabolism
Glioblastoma* / genetics
Glioblastoma* / metabolism
Humans
Lipid Droplets / metabolism
Lipolysis*
Oxidation-Reduction

Substances

Fatty Acids