Germline Predisposition to Prostate Cancer in Diverse Populations

Urol Clin North Am. 2021 Aug;48(3):411-423. doi: 10.1016/j.ucl.2021.03.008. Epub 2021 Jun 12.

Abstract

There remains a paucity of data related to germline genetic alterations predisposing patients to prostate cancer. Recent data suggest that African American, Hispanic, and Asian and Pacific Islander men exhibit genetic alterations in both highly penetrant germline genes, including BRCA1/2, ATM, and CHEK2, and the mismatch repair genes associated with Lynch syndrome, as well as low-penetrant single-nucleotide polymorphisms. However, cohort sizes remain small in many studies limiting the ability to determine clinical significance, appropriate risk stratification, and treatment implications in these diverse populations.

Keywords: African American; Asian; Germline DNA testing; Prostate cancer; Single nucleotide polymorphisms.

Publication types

  • Review

MeSH terms

  • Ataxia Telangiectasia Mutated Proteins
  • BRCA1 Protein
  • Checkpoint Kinase 2
  • Colorectal Neoplasms, Hereditary Nonpolyposis / ethnology
  • Colorectal Neoplasms, Hereditary Nonpolyposis / genetics
  • DNA Mismatch Repair
  • Genetic Predisposition to Disease*
  • Genetic Testing*
  • Germ-Line Mutation*
  • Humans
  • Male
  • Polymorphism, Single Nucleotide
  • Prostatic Neoplasms / ethnology*
  • Prostatic Neoplasms / genetics*
  • Risk Assessment

Substances

  • BRCA1 Protein
  • BRCA1 protein, human
  • Checkpoint Kinase 2
  • ATM protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • CHEK2 protein, human