Aberrations in Lipid Expression and Metabolism in Psoriasis

Int J Mol Sci. 2021 Jun 18;22(12):6561. doi: 10.3390/ijms22126561.

Abstract

Psoriasis (PSO) is a common skin disease that affects about 1%-3% of the general population. It is a great medical, social and economic burden since PSO is associated with many comorbidities, of which the most common are cardiometabolic disorders. Psoriatic patients suffer more frequently from obesity, dyslipidemia, atherosclerosis, and nonalcoholic fatty liver disease. Research shows that lipid expression and metabolism disorders are present more often in such patients. This review focuses on a variety of aberrations in lipids in the skin, blood, and adipose tissue in psoriatic patients and their multifactorial impact on the pathogenesis of psoriasis.

Keywords: cholesterol; fatty acids; lipids; lipoprotein; psoriasis; triglycerides.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Hypolipidemic Agents / therapeutic use
  • Lipid Metabolism*
  • Psoriasis / drug therapy
  • Psoriasis / genetics
  • Psoriasis / metabolism*
  • Up-Regulation

Substances

  • Hypolipidemic Agents