Hyperactivated RAGE in Comorbidities as a Risk Factor for Severe COVID-19-The Role of RAGE-RAS Crosstalk

Biomolecules. 2021 Jun 12;11(6):876. doi: 10.3390/biom11060876.

Abstract

The receptor for advanced glycation-end products (RAGE) is a multiligand receptor with a role in inflammatory and pulmonary pathologies. Hyperactivation of RAGE by its ligands has been reported to sustain inflammation and oxidative stress in common comorbidities of severe COVID-19. RAGE is essential to the deleterious effects of the renin-angiotensin system (RAS), which participates in infection and multiorgan injury in COVID-19 patients. Thus, RAGE might be a major player in severe COVID-19, and appears to be a useful therapeutic molecular target in infections by SARS-CoV-2. The role of RAGE gene polymorphisms in predisposing patients to severe COVID-19 is discussed.&nbsp.

Keywords: AGER polymorphisms; COVID-19 comorbidities; RAGE.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • COVID-19 / genetics
  • COVID-19 / metabolism*
  • COVID-19 / pathology
  • Humans
  • Inflammation / genetics
  • Inflammation / metabolism*
  • Inflammation / pathology
  • Oxidative Stress*
  • Polymorphism, Genetic
  • Receptor for Advanced Glycation End Products / genetics
  • Receptor for Advanced Glycation End Products / metabolism*
  • Renin-Angiotensin System*
  • Risk Factors
  • SARS-CoV-2 / physiology
  • Severity of Illness Index

Substances

  • Receptor for Advanced Glycation End Products