Natural Polymer Chitosan as Super Disintegrant in Fast Orally Disintegrating Meloxicam Tablets: Formulation and Evaluation

Gailute Draksiene; Brigita Venclovaite; Lauryna Pudziuvelyte; Liudas Ivanauskas; Mindaugas Marksa; Jurga Bernatoniene

doi:10.3390/pharmaceutics13060879

Natural Polymer Chitosan as Super Disintegrant in Fast Orally Disintegrating Meloxicam Tablets: Formulation and Evaluation

Pharmaceutics. 2021 Jun 15;13(6):879. doi: 10.3390/pharmaceutics13060879.

Authors

Gailute Draksiene¹, Brigita Venclovaite², Lauryna Pudziuvelyte³, Liudas Ivanauskas⁴, Mindaugas Marksa⁴, Jurga Bernatoniene^{1

3}

Affiliations

¹ Department of Drug Technology and Social Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, LT-50161 Kaunas, Lithuania.
² Department of Clinical Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, LT-50161 Kaunas, Lithuania.
³ Institute of Pharmaceutical Technologies, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, LT-50161 Kaunas, Lithuania.
⁴ Department of Analytical and Toxicological Chemistry, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania.

Abstract

The aim of the present investigation was to formulate fast disintegrating tablets of meloxicam by wet granulation technique using medium molecular weight chitosan. The orally disintegrating tablets of meloxicam with chitosan showed good mechanical and disintegration properties and good dissolution rate when prepared in tablet press using 10.8 kN and 11.0 kN compression force. Chitosan is a suitable biopolymer to moderate the disintegration process in orally disintegrating tablets.

Keywords: chitosan; disintegrating; meloxicam; polymer; solubility; stability studies; tablets.