Abstract
Polyphenols are naturally occurring compounds found in abundance in fruits and vegetables. Their health-promoting properties and their use in the prevention and treatment of many human diseases, including cancer, have been known for years. Many anti-cancer drugs are derived from these natural compounds. Etoposide, which is a semi-synthetic derivative of podophyllotoxin, a non-alkaloid lignan isolated from the dried roots and rhizomes of Podophyllum peltatum or Podophyllum emodi (Berberidaceae), is an example of such a compound. In this review, we present data on the effects of polyphenols on the anti-cancer activity of etoposide in in vitro and in vivo studies.
Keywords:
etoposide; polyphenols; topoisomerase II.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Antineoplastic Agents, Phytogenic / therapeutic use
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Biomarkers
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Disease Models, Animal
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Drug Synergism
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Etoposide / pharmacology*
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Etoposide / therapeutic use
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Humans
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Neoplasms / drug therapy
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Neoplasms / etiology
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Neoplasms / metabolism
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Neoplasms / pathology
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Polyphenols / chemistry
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Polyphenols / pharmacology*
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Polyphenols / therapeutic use
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Structure-Activity Relationship
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Topoisomerase II Inhibitors / pharmacology*
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Topoisomerase II Inhibitors / therapeutic use
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Xenograft Model Antitumor Assays
Substances
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Antineoplastic Agents, Phytogenic
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Biomarkers
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Polyphenols
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Topoisomerase II Inhibitors
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Etoposide