Ingestible devices for studying the gastrointestinal physiology and their application in oral biopharmaceutics

Abstract

Ingestible sensor systems are unique tools for obtaining physiological data from an undisturbed gastrointestinal tract. Since their dimensions correspond to monolithic oral dosage forms, such as enteric coated tablets or hydrogel matrix tablets, they also allow insights into the physiological conditions experienced by non-disintegrating dosage forms on their way through the gastrointestinal tract. In this work, the different ingestible sensor systems which can be used for this purpose are described and their potential applications as well as difficulties and pitfalls with respect to their use are presented. It is also highlighted how the data on transit times, pH, temperature and pressure as well as the data from different animal models commonly used in drug product development such as dogs and pigs have contributed to a deeper mechanistic understanding of oral drug delivery.

Keywords: Atmo Gas capsule; Bravo capsule; Gastrointestinal pH profiles; Gastrointestinal transit; Heidelberg pH capsule; Ingestible devices; Ingestible sensors; IntelliCap; SmartPill.