SARS-Cov-2 Damage on the Nervous System and Mental Health

Mohamed Said Boulkrane; Victoria Ilina; Roman Melchakov; Mikhail Arisov; Julia Fedotova; Lucia Gozzo; Filippo Drago; Weihong Lu; Alexey Sarapultsev; Vadim Tseilikman; Denis Baranenko

doi:10.2174/1570159X19666210629151303

SARS-Cov-2 Damage on the Nervous System and Mental Health

Curr Neuropharmacol. 2022;20(2):412-431. doi: 10.2174/1570159X19666210629151303.

Authors

Affiliations

¹ International Research Centre \'Biotechnologies of the Third Millennium\', ITMO University, Saint-Petersburg, Russia.
² All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plants, a branch of the Federal State Budget Scientific Institution "Federal Scientific Centre VIEV", Moscow, Russia.
³ nternational Research Centre \'Biotechnologies of the Third Millennium\', ITMO University, Saint-Petersburg, Russia.
⁴ Laboratory of Neuroendocrinology, I.P. Pavlov Institute of Physiology RASci., 6 Emb. Makarova, St. Petersburg Russia.
⁵ School of Medical Biology, South Ural State University, 76 Lenin prospect, Chelaybinsk, Russia.
⁶ Department of Biomedical and Biotechnological Sciences, Biological Tower, School of Medicine, University of Catania, Catania, Italy.
⁷ Institute of Extreme Environment Nutrition and Protection, Harbin Institute of Technology, Harbin, China.

Abstract

The World Health Organization declared the pandemic situation caused by SARSCoV- 2 (Severe Acute Respiratory Syndrome Coronavirus-2) in March 2020, but the detailed pathophysiological mechanisms of Coronavirus disease 2019 (COVID-19) are not yet completely understood. Therefore, to date, few therapeutic options are available for patients with mildmoderate or serious disease. In addition to systemic and respiratory symptoms, several reports have documented various neurological symptoms and impairments of mental health. The current review aims to provide the available evidence about the effects of SARS-CoV-2 infection on mental health. The present data suggest that SARS-CoV-2 produces a wide range of impairments and disorders of the brain. However, a limited number of studies investigated the neuroinvasive potential of SARS-CoV-2. Although the main features and outcomes of COVID-19 are linked to severe acute respiratory illness, the possible damages on the brain should be considered, too.

Keywords: COVID-19; SARS-CoV-2; brain disorders; mental health; neuroinvasive potential; neurological diseases.

Publication types

Review

MeSH terms

COVID-19*
Humans
Mental Health
Nervous System Diseases* / etiology
SARS-CoV-2

Grants and funding

20-515-55003/RFBR/NSFC