RETRACTED: Exosomal microRNA-16-5p from adipose mesenchymal stem cells promotes TLR4-mediated M2 macrophage polarization in septic lung injury

Int Immunopharmacol. 2021 Sep:98:107835. doi: 10.1016/j.intimp.2021.107835. Epub 2021 Jun 27.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). The authors have requested that this paper be retracted as they were unable to replicate the experimental data reported in Figure 1A. The authors posit that changes in reagents or experimental conditions might be the source of their inability to do so. Additional concerns were raised about the reliability of the Western blot results in Figure 1E, Figure 4B and F, Figure 5B, and Figure 6B, as regarding ‘morphology space’ similarities contained within a series of papers with distinctive eyebrow blots, tabulated here (https://docs.google.com/spreadsheets/d/149EjFXVxpwkBXYJOnOHb6RhAqT4a2llhj9LM60MBffM/edit#gid=0 [nam11.safelinks.protection.outlook.com] [nam11.safelinks.protection.outlook.com]). The journal requested the authors comment on these concerns and provide raw data. However, the authors were not able to fulfil this request and therefore the Editor-in-Chief decided to retract the article.

Keywords: Adipose mesenchymal stem cells; Exosomes; Inflammation; Lung injury; Macrophage; Polarization; Sepsis; Toll-like Receptor 4; microRNA-16-5p.

Publication types

  • Retracted Publication

MeSH terms

  • Acute Lung Injury / genetics
  • Acute Lung Injury / immunology*
  • Adipose Tissue / pathology*
  • Animals
  • Cecum / surgery
  • Cell Differentiation
  • Cytokines / metabolism
  • Disease Models, Animal
  • Exosomes / metabolism*
  • Humans
  • Macrophages / immunology*
  • Mesenchymal Stem Cells / physiology*
  • Mice
  • MicroRNAs / genetics*
  • RAW 264.7 Cells
  • Sepsis / genetics
  • Sepsis / immunology*
  • Th2 Cells / immunology
  • Toll-Like Receptor 4 / metabolism

Substances

  • Cytokines
  • MicroRNAs
  • Mirn16 microRNA, mouse
  • Toll-Like Receptor 4