Celastrol alleviates comorbid obesity and depression by directly binding amygdala HnRNPA1 in a mouse model

Clin Transl Med. 2021 Jun;11(6):e394. doi: 10.1002/ctm2.394.

Authors

Chunyan Zhu¹, Jun Yang¹, Yongping Zhu¹, Jiahao Li¹, Hongyu Chi¹, Congmin Tian¹, Yuqing Meng¹, Yanqing Liu¹, Jigang Wang^{1

2

3}, Na Lin¹

Affiliations

¹ Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
² Shenzhen People's Hospital, Shenzhen, China.
³ Central People's Hospital of Zhanjiang, Zhanjiang, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Amygdala / metabolism*
Animals
Comorbidity
Depression / complications
Depression / drug therapy*
Depression / metabolism
Depression / pathology
Disease Models, Animal*
Heterogeneous Nuclear Ribonucleoprotein A1 / genetics
Heterogeneous Nuclear Ribonucleoprotein A1 / metabolism*
Mice
Obesity / complications
Obesity / drug therapy*
Obesity / metabolism
Obesity / pathology
Pentacyclic Triterpenes / pharmacology*

Substances

Heterogeneous Nuclear Ribonucleoprotein A1
Hnrnpa1 protein, mouse
Pentacyclic Triterpenes
celastrol