Thrombosis in myeloproliferative neoplasms: update in pathophysiology

Brandi N Reeves; Alison R Moliterno

doi:10.1097/MOH.0000000000000664

Thrombosis in myeloproliferative neoplasms: update in pathophysiology

Curr Opin Hematol. 2021 Sep 1;28(5):285-291. doi: 10.1097/MOH.0000000000000664.

Authors

Brandi N Reeves¹, Alison R Moliterno²

Affiliations

¹ Hematology Division, Department of Medicine, Blood Research Center, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
² Hematology Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

PMID: 34183535
DOI: 10.1097/MOH.0000000000000664

Abstract

Purpose of review: This review summarizes high-impact research in myeloproliferative neoplasms (MPN) from the last 18 months, with a particular focus on basic science findings.

Recent findings: A pseudo-hypoxia state with stabilization of hypoxia-inducible factor (HIFα exists that is central to cell growth, cell renewal, inflammation, and thrombotic potential in MPN hematopoietic cells.

Summary: HIFα and inflammatory pathways are new therapeutic targets in MPN, with the potential to ameliorate thrombotic risk and perhaps eradicate mutant progenitor cells.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Hematologic Neoplasms* / complications
Hematologic Neoplasms* / genetics
Hematologic Neoplasms* / metabolism
Hematopoietic Stem Cells / metabolism*
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / genetics
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
Inflammation / genetics
Inflammation / metabolism
Myeloproliferative Disorders* / complications
Myeloproliferative Disorders* / genetics
Myeloproliferative Disorders* / metabolism
Neoplasm Proteins / metabolism
Thrombosis* / etiology
Thrombosis* / genetics
Thrombosis* / metabolism

Substances

HIF1A protein, human
Hypoxia-Inducible Factor 1, alpha Subunit
Neoplasm Proteins