New Advances in the Biosynthesis of Glycopeptide Antibiotics of the Vancomycin Type from Amycolatopsis mediterranei

Roderich D Süssmuth; Stefan Pelzer; Graeme Nicholson; Tilmann Walk; Wolfgang Wohlleben; Günther Jung

doi:10.1002/(SICI)1521-3773(19990712)38:13/14<1976::AID-ANIE1976>3.0.CO;2-3

New Advances in the Biosynthesis of Glycopeptide Antibiotics of the Vancomycin Type from Amycolatopsis mediterranei

Angew Chem Int Ed Engl. 1999 Jul 12;38(13-14):1976-1979. doi: 10.1002/(SICI)1521-3773(19990712)38:13/14<1976::AID-ANIE1976>3.0.CO;2-3.

Authors

Roderich D Süssmuth¹, Stefan Pelzer², Graeme Nicholson¹, Tilmann Walk¹, Wolfgang Wohlleben², Günther Jung¹

Affiliations

¹ Institut für Organische Chemie der Universität, Auf der Morgenstelle 18, D-72076 Tübingen (Germany), Fax: (+49) 7071-29-5560.
² Lehrstuhl Mikrobiologie/Biotechnologie der Universität, Auf der Morgenstelle 28, D-72076 Tübingen (Germany).

Abstract

Linear biosynthesis products from balhimycin, a tricyclic glycopeptide antibiotic of the vancomycin type, were isolated from mutants of Amycolatopsis mediterranei. The structures of these intermediates, determined by NMR spectroscopy, give new impulses for the understanding of the vancomycin biosynthesis.

Keywords: Balhimycin; Biosynthesis; Glycopeptides; Structure elucidation; Vancomycin.