A new triarylindanone and a new isobenzofuranone derivative from Selaginella tamariscina

Yu-Jie Peng; Dan Zhang; Wan-Ling Chen; Si-Yi Wang; Yao Zhang; Hui Zou; Hong-Ling Xiang; Ge-Lei Xiao

doi:10.1080/14786419.2021.1938042

A new triarylindanone and a new isobenzofuranone derivative from Selaginella tamariscina

Nat Prod Res. 2022 Oct;36(20):5387-5392. doi: 10.1080/14786419.2021.1938042. Epub 2021 Jun 28.

Authors

Yu-Jie Peng¹, Dan Zhang¹, Wan-Ling Chen¹, Si-Yi Wang¹, Yao Zhang¹, Hui Zou^{1

2}, Hong-Ling Xiang¹, Ge-Lei Xiao^{3

4}

Affiliations

¹ Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha, Hunan, PR China.
² Key Laboratory of Epigenetics and Oncology, Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, Sichuan, China.
³ Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
⁴ Diagnosis and Treatment Center for Hydrocephalus, Xiangya Hospital, Central South University, Changsha, Hunan, PR China.

PMID: 34180326
DOI: 10.1080/14786419.2021.1938042

Abstract

A new triarylindanone, namely selagindanone A (1), and a new isobenzofuranone (2), 3,4-bis(4-hydroxyphenyl)isobenzofuran-1(3H)-one, were isolated from Selaginella tamariscina. Their structures were elucidated by comprehensive spectroscopic and mass spectrometric analyses, including 1 D-, 2 D-NMR and HR-ESI-MS. Compound 1 possesses a unique structural feature of triaryl-substituted in the skeleton of 1-indanone. In addition, compound 2 showed weak cytotoxicity against human hepatocellular carcinoma SMMC-7721 and HepG2 cell lines.

Keywords: 3,4-bis(4-hydroxyphenyl)isobenzofuran-1(3H)-one; Selaginella tamariscina; cytotoxicity; isobenzofuranone; selagindanone A; triaylindanone.

MeSH terms

Humans
Indans
Magnetic Resonance Spectroscopy
Molecular Structure
Selaginellaceae* / chemistry

Substances

Indans