TFA-catalyzed Q-Tube Reactor-Assisted Strategy for the Synthesis of Pyrido[1,2- b][1,2,4]triazine and Pyrido[1',2':2,3][1,2,4]triazino[5,6- b]indole Derivatives

Hamada Mohamed Ibrahim; Haider Behbehani

doi:10.1021/acsomega.1c01980

TFA-catalyzed Q-Tube Reactor-Assisted Strategy for the Synthesis of Pyrido[1,2- b][1,2,4]triazine and Pyrido[1',2':2,3][1,2,4]triazino[5,6- b]indole Derivatives

ACS Omega. 2021 Jun 8;6(24):16086-16099. doi: 10.1021/acsomega.1c01980. eCollection 2021 Jun 22.

Authors

Hamada Mohamed Ibrahim^{1

2}, Haider Behbehani¹

Affiliations

¹ Chemistry Department, Faculty of Science, Kuwait University, P.O. Box 5969, Safat 13060, Kuwait.
² Chemistry Department, Faculty of Science, Fayoum University, P.O. Box 63514, Fayoum 63514, Egypt.

Abstract

An efficient high-pressure-assisted trifluoroacetic acid-catalyzed protocol for synthesizing unreported novel pyrido[1,2-b][1,2,4]triazine and pyrido[1',2':2,3][1,2,4]triazino[5,6-b]indole derivatives has been established. This strategy includes the condensation reactions of various 1-amino-2-imino-4-arylpyridine-3-carbonitrile derivatives with indoline-2,3-dione (isatin) derivatives and α-keto acids such as pyruvic acid and phenylglyoxylic acid. This strategy includes utilizing the Q-tube reactor as an efficient and safe tool to conduct these reactions under high-pressure conditions. In addition, trifluoroacetic acid was used to induce this transformation. In this research, conducting the targeted reactions under high pressure using the Q-tube reactor was found to be superb in comparison to that under the traditional refluxing conditions. X-ray single-crystal analysis was utilized in this study to authenticate the structure of the synthesized products.